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The authors performed a systematic review and meta-analysis that evaluated the prophylactic effect of aspirin during pregnancy. Sixteen trials including 18,907 participants provided data for preterm and term preeclampsia. Findings suggest that Aspirin reduces the risk of preterm preeclampsia but not term preeclampsia, and only when it is initiated at ≤16 weeks of gestation and at a daily dose of ≥100 mg.


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  2. Roberge, S., Nicolaides, K., Demers, S., Hyett, J., Chaillet, N., Bujold, E. The role of aspirin dose on the prevention of preeclampsia and fetal growth restriction: systematic review and meta-analysis. Am J Obstet Gynecol2017;216:110–120.e1-6.

  3. Rolnik, D.L., Wright, D., Poon, L.C. et al, Aspirin versus placebo in pregnancies at high risk for preterm preeclampsia. N Engl J Med2017;77:613–622.